PARP-1抑制剂,PARP-1 inhibitor
1)PARP-1 inhibitorPARP-1抑制剂
1.To construct the pharmacophore model of the poly(ADP-ribose) polymerase-1 inhibitor and to investigate the possible inhibitory mechanisms,ten pharmacophore models ofPARP-1 inhibitor were established from the training set of thirty-eightPARP-1 inhibitors with conformer analysis and pharmacophore mapping by using the Catalyst software.结合PARP-1的作用机制等因素,得到一个含有两个氢键接受体和两个芳香疏水性基团的PARP-1抑制剂药效团模型。
英文短句/例句
1.STUDY ON THE EFFECT OF PARP-1 INHIBITOR PJ34 ON RATS WITH FOCAL CEREBRAL ISCHEMIA-REPERFUSION INJURYPARP-1抑制剂PJ34对大鼠局灶脑缺血再灌注损伤的影响
2.Study of Protective Effect of PARP Inhibitor PJ34 on a Mouse Model of Parkinson"s Disease;PARP抑制剂PJ34对帕金森病模型鼠保护作用的研究
3.Effects of Poly(ADP-ribose) Polymerase Inhibitor in Streptozotocin-diabetic Rat Model of Early Peripheral Neuropathy;PARP抑制剂对糖尿病大鼠早期神经病变的影响
4.Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/-Mice with HyperhomocysteinemiaPARP抑制剂延缓高同型半胱氨酸血症诱导ApoE-/-小鼠动脉粥样硬化斑块进展
5.Expression and significance of PARP-1 protein EL-4 cells induced by low dose ionizing radiation低剂量电离辐射诱导的EL-4细胞PARP-1蛋白表达及其意义的研究
6.The Effect of 5-AIQ-Induced PARP Inhibition on the Proliferation of Murine Colon Carcinoma CT26 Cell Lines and Its Mechanism;5-AIQ抑制PARP对结肠癌CT26细胞增殖影响及其机制探讨
7.The Effect of PARP Inhibition on the Invasion of Murine Colon Carcinoma CT26 Cell Lines and Its Mechanism;PARP抑制对小鼠结肠癌CT26细胞侵袭影响及其机制探讨
8.The Effect of Parp Inhibiton on the Adherence of Platelets to Mouse Colon Carcinoma CT26 Cell Lines and Its Mechanism;PARP抑制对小鼠结肠癌CT26细胞与血小板粘附影响及其机制探讨
9.The Effect of PARP Inhibition on the Liver Metastasis of Mouse Colon Adenocarcinoma CT26 Cell Line in Vivo and Its Mechanism;PARP抑制对小鼠结肠腺癌CT26细胞肝转移的影响及其机制探讨
10.Studies on the Screening Method of HIV-1 Reverse Transcriptase Inhibitors;HIV-1逆转录酶抑制剂筛选方法的研究
11.The Discovery of Novel Caspse-1 Inhibitors;新型Caspase-1小分子抑制剂的发现
12.Study on Synthesis of Capsid Protein Inhibitor CAP-1 Derivatives;HIV-1衣壳蛋白抑制剂CAP-1衍生物的合成
13.Preparation and Performance Evaluation of Hydrate Kinetic Inhibitor GHI-1动力学水合物抑制剂GHI-1的研制及性能评价
14.HIV-1 Integrase Inhibitors: Design Synthesis and Biological Activities;HIV-1整合酶抑制剂的设计、合成与活性研究
15.Binding Mode Study of Streptolydigin, an HIV-1 Protease Inhibitor via Docking Methodology;HIV-1蛋白酶抑制剂—利迪链菌素的分子对接研究
16.Screening and Identification of Inhibitors on HIV-1 Integrase;HIV-1整合酶抑制剂的筛选及其活性的测定
17.A Novel Peptide That Inhibits HIV-1 Entry;一种新型多肽类HIV-1进入抑制剂的初步研究
18.Inhibitiory Effect on the Proliferation of Human Renal Carcinoma Cell Line GRC-1 by Blockers of Chloride Channel;氯通道阻断剂抑制人肾癌细胞株GRC-1的增殖
相关短句/例句
inhibitor of PARPPARP抑制剂
3)HIF-1 inhibitorsHIF-1抑制剂
4)Calpain inhibitor 1calpain抑制剂-1
5)PAI-1 inhibitoDPAI-1抑制剂
6)caspase-1 inhibitorcaspase-1抑制剂
延伸阅读
cAMP磷酸二酯酶抑制剂分子式：CAS号：性质：一类能抑制cAMP磷酸二酯酶活性的化合物，是一类具有新机理的强心药。cAMP磷酸二酯酶是在与Ca2+结合的钙调素激活下分解环腺苷酸的酶。cAMP磷酸二酯酶抑制剂能抑制心肌和血管平滑肌细胞内的第三型磷酸二酯酶的活性，使细胞内cAMP含量增加，从而增强心肌收缩，扩张外周血管，改善心力衰竭病人的血流动力学。临床短期使用对急性心力衰竭有明显疗效，但长期使用则引起不良后果。根据对不同亚型的cAMP磷酸二酯酶的亲和力，可分成非选择性抑制剂和选择性抑制剂。
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