VEGF发卡状核酶,VEGF hairpin ribozyme
1)VEGF hairpin ribozymeVEGF发卡状核酶
1.Objective: To observe the effects of recombinant Ad-deliveredVEGF hairpin ribozyme(VEGF/Rz) on cell growth and VEGF expression of lung adenocarcinoma cell line A549 in vitro.目的:将携有VEGF发卡状核酶(VEGF/Rz)和绿色荧光蛋白(GFP)的重组腺病毒(Ad-VEGF/Rz-GFP)感染肺腺癌A549细胞,观察VEGF发卡状核酶对肺腺癌A549细胞生长和VEGF表达的影响。
英文短句/例句
1.The Study of Anti-Human VEGF Ribozyme Treatment on Hepatocellular Carcinoma;抗人VEGF发卡状核酶治疗肝癌的实验研究
2.Construction of adenovirus expressing anti-vascular endothelial growth factor hairpin ribozyme and its inhibition of growth of colorectal cancer HT-29 cells表达抗-VEGF发夹状核酶腺病毒载体的构建及其对结肠癌生长的抑制作用
3.The Latent Membrane Protein-1 Gene Silence by Combination Treatment of Short Hairpin RNA and Deoxyribozyme in Nasopharyngeal Carcinoma;小发卡状RNA联合脱氧核酶抑制鼻咽癌EBV-LMP1基因表达的实验研究
4.Experimental Study on Inhibitory Effects to RSV Infection by Combination Treatment of Short Hairpin RNA and Deoxyribozyme;小发卡结构状RNA联合脱氧核酶抗呼吸道合胞病毒实验研究
5.The Effects of Recombinant Ad-delivered VEGF Ribozyme on Cell Growth and VEGF Expression of Lung Adenocarcinoma Cell Line A549重组腺病毒介导的VEGF核酶对肺腺癌A549细胞生长及VEGF表达的影响
6.axehead ribozyme斧头（状）核酶[见于delta肝炎病毒]
7.The Software Design for OBS Network Core Node Control Card;光突发交换核心节点控制卡软件设计
8.The Implement Of ASI Transmitter Based On Altera ASI IP Core基于Altera ASI IP核的ASI发送卡实现
9.Construction and identification of plasmid vector of short interfering RNA on pneumocystis carinii thymidylate synthase gene卡氏肺孢子胸腺嘧啶核苷酸合酶基因siRNA表达载体的构建和鉴定
10.BAL 31 nucleasebal 31核酸酶
11.Antiangiogenesis and Enhancing Function of Leukemic Dendritic Cell by VEGF Antisense Oligodeoxynucleotide;VEGF反义寡核苷酸抗白血病血管新生和增强白血病源性树突状细胞功能的研究
12.The Expression and Purification of SARS-CoV RNA Dependent RNA PolymeraseSARS冠状病毒RNA依赖的RNA聚合酶原核和真核表达及纯化
13.Present Status of Study on the Characterization and Progression of Deoxyribonuclease Ⅱ Family脱氧核糖核酸酶Ⅱ(DNaseⅡ)家族及其类似物的性质和研究现状
14.Reserch on the Status and Countermeasures of Bank Card Market in Our Country;我国银行卡市场发展状况与对策研究
15.The Hardware Design for OBS Network Core Router Control Card;光突发交换网络核心节点控制卡硬件设计
16.New 5′-nucleotide phosphodiesterase abnormal isoenzyme discovered in sera of patients with hepatoma在肝癌病人血清中发现5′-核苷酸磷酸二酯酶新的异常同工酶
17.Significance of VEGF&VEGF-C Expression in Differentiated Thyroid Carcinoma;分化型甲状腺癌中VEGF和VEGF-C的表达及意义
18.Expression and significance of VEGF-C and VEGF-D in differentiated thyroid carcinomaVEGF-C和VEGF-D在分化型甲状腺癌中的表达及意义
相关短句/例句
anti-VEGF hairpin ribozyme抗-VEGF发夹状核酶
1.In this study, we constructed an adenovirus that simultaneously expressesanti-VEGF hairpin ribozyme and human IL-24 and examined its VEGF expression inhibitory effect and anti-tumor efficacy against human colon cancer HT-29 cells in vitro and in vivo.RT-PCR及免疫荧光法检测病毒感染后抗-VEGF发夹状核酶及白细胞介素-24在HT-29细胞中的表达,Real-time PCR及ELISA检测其对VEGF mRNA及蛋白表达的抑制作用,
3)Leukemia cell mode抗VEGF发夹状核酶基因
4)Hairpin ribozyme发卡状核酶
1.Hairpin ribozyme targeted vascular endothelial growth factor(VEGF) inhibited the expression of VEGF and the growth of xenografted tumors;抗VEGF发卡状核酶抑制肝癌VEGF表达和移植瘤生长
5)Hairpin ribozyme gene发夹状核酶
1.To explore the possibility of inhibiting expression of VEGF in leukemia cells and observe whether the growth, apoptosis and tumorigenesis of cells could be affected after anti-VEGF hairpin ribozyme gene was introduced into the K.目的:运用血管内皮生长因子(Vascular endothelial growth factor,VEGF)抗体阻断白血病K562细胞株VEGF的自分泌作用,探讨其对K562细胞增殖、凋亡及相关基因表达的影响;将携带抗VEGF发夹状核酶基因的真核表达载体转导白血病细胞株K562,建立稳定表达的细胞株克隆,探讨抗VEGF发夹状核酶基因对K562细胞增殖、凋亡等生物学行为的影响及其分子机制;构建血管内皮细胞生长因子受体(VEGFR)Flt-1和KDR特异性短发夹环RNA(shRNA)真核表达载体,并将Flt-1ShRNA导入白血病细胞株K562,观察对白血病细胞Flt-1基因表达的作用,并探讨其对白血病细胞浸润能力的影响及其机制。
6)hairpin ribozyme gene发夹状核酶基因
1.Objective To explore the potential effects of anti-VEGFhairpin ribozyme gene to gene expression profiles in leukemia cell line K562.方法采用脂质体介导的方法将抗VEGF发夹状核酶基因真核表达载体pcDNA-RZ转染白血病细胞株K562、G418抗性筛选获得阳性克隆;抽提基因组DNA,用PCR方法验证核酶基因已转入K562细胞;荧光定量PCR和免疫印迹反应检测白血病细胞中VEGFmRNA和蛋白表达量的改变;应用cDNA微阵列技术检测VEGF基因表达下调对白血病K562细胞株基因表达谱的影响。
延伸阅读
VEGF分子式：CAS号：性质：又称血管通透因子(vascular permeability factor)。1989首先从牛垂体滤泡状细胞培养液中分离纯化。有四种不同形式，成熟单体，分别为121，165，189和206个氨基酸，目前分离得到的VEGF，均由两个相同多肽链通过二硫键构成的同源二聚体，亚基分子量18 000～24 000，总蛋白分子量34 000～46 000。蛋白质表面有许多阳离子，呈强碱性，等电点高，对酸碱热稳定。VEGF是一类糖蛋白，可与肝素结合，多糖链仅与其分泌功能有关，与生物活性无关。VEGF 121/165为可溶性分泌蛋白。VEGF 189/206几乎都结合在质膜或基底膜上的含有肝素的蛋白聚糖上。四种VEGF的生物活性无明显差异。VEGF是一类多功能生长因子，能特异性作用于血管内皮细胞，强烈促进其增殖，促进血管形成，并有升高血管通透性的作用。多种细胞有分泌VEGF的功能，并通过旁分泌方式作用于血管内皮细胞。对血管内皮细胞的促有丝分裂作用十分强烈，可明显促进血管生成，能引起血管通透性增加，且是最强烈的引起血管通透性增加的物质。1nmol/L即可起作用，为组胺的50 000倍。用于心血管疾病、肿瘤、创伤修复等。
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